RAPGEF1

Across TCGA patient cohorts, RAPGEF1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,304 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RAPGEF1-associated genes across cancer lineages are CCR1, IRF8, and GLIPR1. Each is linked with RAPGEF1 in more than 7 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPGEF1 versus CCR1 in UCEC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCR1 →	+1.053	+0.293	<.001	<.001	3	8
OV	IRF8 →	+1.073	+0.291	.002	.002	3	8
BRCA	GLIPR1 →	+0.724	+0.208	.002	<.001	3	7
OV	SELL →	+1.156	+0.312	.005	.001	3	7
OV	FGR →	+0.961	+0.342	.001	<.001	3	7
UCEC	CYTH4 →	+1.078	+0.279	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,304 associations by consensus.

RAPGEF1 vs CCR1 — UCEC

Explore this scatter interactively →