RAPGEF1

Across TCGA patient cohorts, RAPGEF1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAPGEF1-associated genes across cancer lineages are eIF4E, MEK1, and MSH2. Each is linked with RAPGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RAPGEF1-low versus RAPGEF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.172	+1.807	.006	<.001	3	2
UCEC	MEK1 →	+0.370	+2.321	<.001	<.001	3	2
COAD	MSH2 →	-0.273	-3.169	.001	.017	3	2
COAD	MSH6 →	-0.485	-2.196	.001	.010	3	2
UCEC	p53 →	-0.273	-1.378	.018	.008	3	2
UCEC	PDCD4 →	-0.468	-4.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by RAPGEF1 expression — UCEC

Explore this box plot interactively →