RAPGEF1

Across TCGA cell cohorts, RAPGEF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,157 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RAPGEF1-associated GO terms across cancer lineages are CTP salvage, Phosphatidylinositol biosynthetic process, and Cytosolic transport. Each is linked with RAPGEF1 in more than 14 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTP salvage grouped by RAPGEF1-low versus RAPGEF1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CTP salvage →	+0.132	+1.263	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.060	+1.113	.001	<.001	3	15
STOMACH	Cytosolic transport →	+0.085	+1.424	.002	<.001	2	14
STOMACH	Positive regulation of TORC2 signaling →	+0.175	+1.434	.001	<.001	3	13
LUNG_NSCLC_LUAD	Response to starvation →	+0.057	+0.897	<.001	<.001	3	13
OVARY	Transcription initiation-coupled chromatin remodeling →	+0.078	+1.194	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,157 associations by consensus.

CTP salvage by RAPGEF1 expression — SOFT_TISSUE

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