RAPGEF1

Across TCGA cell cohorts, RAPGEF1 mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAPGEF1-associated genes across cancer lineages are GH2, DEFA6, and SIGLECL1. Each is linked with RAPGEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF1-to-partner and partner-to-RAPGEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GH2 grouped by RAPGEF1-low versus RAPGEF1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF1→partner) and Y-score (partner→RAPGEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GH2 →	+0.148	+3.700	<.001	.003	3	2
LUNG_NSCLC_LUAD	DEFA6 →	+0.167	+5.228	<.001	.005	3	2
LUNG_NSCLC_LUAD	SIGLECL1 →	+0.036	+6.266	<.001	<.001	3	2
OVARY	RAX →	+0.288	+3.984	<.001	.001	3	2
LARGE_INTESTINE	PLA2G3 →	+1.116	+2.710	<.001	.004	3	2
PANCREAS	CCKAR →	+0.072	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

GH2 by RAPGEF1 expression — CNS

Explore this box plot interactively →