RAP2C

Across TCGA pan-cancer cohorts, RAP2C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RAP2C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where RAP2C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RAP2C is over-expressed in tumor.

LSCC, PDAC, and LUAD are the cancer types where RAP2C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP2C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.150	<.001	4	view →
PDAC	Female	All	+0.367	.009	3	view →
LUAD	All	All	+0.113	.023	3	view →
COAD	Female	All	+0.239	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RAP2C–LSCC

Open the LSCC breakdown →