RAP1GAP2

Across TCGA pan-cancer cohorts, RAP1GAP2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RAP1GAP2’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RAP1GAP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAP1GAP2 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

PDAC, COAD, and LSCC are the cancer types where RAP1GAP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP1GAP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	−0.753	<.001	8	view →
COAD	Male	All	−0.365	<.001	8	view →
LSCC	Male	II,III,IV	−0.328	<.001	6	view →
CCRCC	Male	II,III,IV	−0.218	.002	6	view →
LUAD	Female	All	−0.292	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RAP1GAP2–PDAC

Open the PDAC breakdown →