RAP1GAP2

Across TCGA patient cohorts, RAP1GAP2 mutation is significantly associated with the RNA expression of many other genes, with 4,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1GAP2-associated genes across cancer lineages are ATP6V1D, NDUFC1, and RPF1. Each is linked with RAP1GAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAP1GAP2-to-partner and partner-to-RAP1GAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1D grouped by RAP1GAP2-low versus RAP1GAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GAP2→partner) and Y-score (partner→RAP1GAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1D →	+0.486	+3.523	<.001	<.001	3	3
UCEC	NDUFC1 →	+0.369	+2.021	<.001	<.001	3	3
UCEC	RPF1 →	+0.477	+2.021	<.001	<.001	3	3
UCEC	DAD1 →	+0.405	+1.827	<.001	<.001	3	3
UCEC	GTF2B →	+0.422	+2.279	<.001	<.001	3	3
UCEC	NKD2 →	-0.814	-1.584	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,923 associations by consensus.

ATP6V1D by RAP1GAP2 expression — UCEC

Explore this box plot interactively →