RAP1GAP2

Across TCGA cell cohorts, RAP1GAP2 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAP1GAP2-associated genes across cancer lineages are PRR30, GUCA1A, and GML. Each is linked with RAP1GAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1GAP2-to-partner and partner-to-RAP1GAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by RAP1GAP2-low versus RAP1GAP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GAP2→partner) and Y-score (partner→RAP1GAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRR30 →	+0.014	+3.643	<.001	.007	3	2
BLOOD_Leukemia	GUCA1A →	+0.099	+3.874	<.001	.006	3	2
BLOOD_Leukemia	GML →	+0.057	+3.567	.001	.003	3	1
BLOOD_Leukemia	GALNTL5 →	+0.011	+4.569	<.001	.003	3	1
BLOOD_Leukemia	CCKBR →	+0.596	+3.864	.001	.003	3	1
BLOOD_Leukemia	ADAM30 →	+0.011	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PRR30 by RAP1GAP2 expression — CNS

Explore this box plot interactively →