RAP1GAP

Across TCGA pan-cancer cohorts, RAP1GAP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAP1GAP data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RAP1GAP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP1GAP expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where RAP1GAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.311	0.968	.001	16	view →
UCEC	DFS	Quartile	All	0.979	0.789	.019	14	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	5	view →
GBM	DFS	Tertile	All	0.799	0.582	.021	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAP1GAP–LUAD (DFS)

Open the LUAD breakdown →