RAP1AP

Across TCGA pan-cancer cohorts, RAP1AP RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RAP1AP data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher RAP1AP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP1AP expression acts as an unfavorable survival marker, although some lineages such as LUAD and BRCA show a favorable association.

LUSC, LUAD, and KIRC are the cancer types where RAP1AP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	II,III,IV	0.273	0.556	<.001	59	view →
LUAD	OS	Quartile	All	0.811	0.624	.002	50	view →
KIRC	DFS	Quartile	IV	0.159	0.514	.004	37	view →
ACC	OS	Median	All	0.313	0.858	<.001	35	view →
BRCA	DFS	Tertile	III,IV	0.929	0.825	.012	31	view →
ESCA	OS	Tertile	III,IV	0.811	0.452	.005	27	view →
UCS	DFS	Tertile	IV	0.981	0.426	.017	24	view →
STAD	DFS	Tertile	All	0.474	0.623	.020	23	view →
THCA	OS	Tertile	All	1.000	0.899	.004	23	view →
LGG	DFS	Quartile	All	0.757	0.879	.002	19	view →
CESC	OS	Tertile	IV	0.712	0.244	.027	18	view →
PAAD	DFS	Tertile	All	0.197	0.389	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RAP1AP–LUSC (DFS)

Open the LUSC breakdown →