RAP1A

Across TCGA pan-cancer cohorts, RAP1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAP1A data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RAP1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP1A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where RAP1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.546	1.000	.013	14	view →
UCEC	DFS	Median	All	0.936	1.000	.022	8	view →
LSCC	DFS	Median	II,III,IV	0.549	0.801	.032	3	view →
PDAC	DFS	Tertile	III,IV	0.232	0.473	.036	2	view →
HNSC	OS	Quartile	All	0.931	0.793	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAP1A–LUAD (DFS)

Open the LUAD breakdown →