RAP1A

Across TCGA patient cohorts, RAP1A mutation is significantly associated with the RNA expression of many other genes, with 1,541 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1A-associated genes across cancer lineages are RNU2-47P, HSPE1-MOB4, and GCATP1. Each is linked with RAP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1A-to-partner and partner-to-RAP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-47P grouped by RAP1A-low versus RAP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1A→partner) and Y-score (partner→RAP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU2-47P →	+0.087	+4.153	<.001	.005	3	2
UCEC	HSPE1-MOB4 →	+0.179	+2.536	<.001	.001	3	1
UCEC	GCATP1 →	+0.475	+2.609	<.001	.005	3	1
UCEC	BNIP3P4 →	+0.068	+2.784	<.001	.004	3	1
UCEC	POM121C →	+0.490	+3.346	<.001	.005	3	1
UCEC	RBAK-RBAKDN →	+0.095	+2.208	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,541 associations by consensus.

RNU2-47P by RAP1A expression — UCEC

Explore this box plot interactively →