RAP1A

Across TCGA patient cohorts, RAP1A mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1A-associated genes across cancer lineages are eEF2, EGFR_pY1068, and EGFR_pY1173. Each is linked with RAP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1A-to-partner and partner-to-RAP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RAP1A-low versus RAP1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1A→partner) and Y-score (partner→RAP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.382	+3.169	.014	.018	3	1
UCEC	EGFR_pY1068 →	-0.293	-3.584	.007	.002	3	1
UCEC	EGFR_pY1173 →	+0.081	+1.611	.020	.043	3	1
UCEC	ERK2 →	+0.215	+2.115	.010	.019	3	1
UCEC	HER2_pY1248 →	-0.231	-2.807	.047	.003	3	1
UCEC	INPP4B →	-0.316	-3.169	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by RAP1A expression — UCEC

Explore this box plot interactively →