RANGRF

Across TCGA pan-cancer cohorts, RANGRF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RANGRF data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RANGRF mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RANGRF expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where RANGRF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.898	.035	8	view →
HNSC	DFS	Median	III,IV	0.935	1.000	.035	5	view →
LSCC	DFS	Tertile	All	0.620	0.852	.027	4	view →
PDAC	DFS	Tertile	III,IV	0.872	0.177	.024	3	view →
GBM	DFS	Quartile	All	0.419	0.216	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RANGRF–UCEC (OS)

Open the UCEC breakdown →