RANGAP1

Across TCGA pan-cancer cohorts, RANGAP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RANGAP1 data layer compared with 30 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RANGAP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RANGAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where RANGAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.926	0.714	.014	24	view →
LSCC	DFS	Median	II,III,IV	0.855	0.687	.026	10	view →
CCRCC	OS	Quartile	III,IV	0.383	0.891	.012	9	view →
LUAD	OS	Tertile	All	0.659	1.000	.015	9	view →
OV	DFS	Quartile	All	0.884	0.533	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RANGAP1–HNSC (DFS)

Open the HNSC breakdown →