RANGAP1

Across TCGA patient cohorts, RANGAP1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANGAP1-associated genes across cancer lineages are eIF4E, Cyclin-E2, and eEF2. Each is linked with RANGAP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RANGAP1-to-partner and partner-to-RANGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RANGAP1-low versus RANGAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANGAP1→partner) and Y-score (partner→RANGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+2.115	.042	.019	3	4
STAD	Cyclin-E2 →	+0.306	+3.021	<.001	.018	3	2
UCEC	eEF2 →	+0.397	+3.169	.011	.018	3	2
UCEC	MIG-6 →	+0.093	+1.884	.033	.030	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.115	.019	.019	3	2
UCEC	PDCD4 →	-0.546	-2.312	.007	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by RANGAP1 expression — UCEC

Explore this box plot interactively →