RANGAP1

Across TCGA cell cohorts, RANGAP1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RANGAP1-associated genes across cancer lineages are TSHB, TCF23, and MT4. Each is linked with RANGAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RANGAP1-to-partner and partner-to-RANGAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by RANGAP1-low versus RANGAP1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANGAP1→partner) and Y-score (partner→RANGAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TSHB →	+0.164	+5.022	<.001	.002	3	1
SKIN	TCF23 →	+0.007	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	MT4 →	+2.631	+3.556	<.001	.007	3	1
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	OR2T8 →	+0.164	+3.693	.001	.005	3	1
LARGE_INTESTINE	C10orf53 →	+0.017	+4.632	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TSHB by RANGAP1 expression — SKIN

Explore this box plot interactively →