RANBP3L

Across TCGA patient cohorts, RANBP3L mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANBP3L-associated genes across cancer lineages are JNK_pT183_Y185, JNK2, and MEK1. Each is linked with RANBP3L in more than 1 cancer types. Because this analysis shows association rather than direction, both RANBP3L-to-partner and partner-to-RANBP3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RANBP3L-low versus RANBP3L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP3L→partner) and Y-score (partner→RANBP3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK_pT183_Y185 →	+0.192	+3.000	.014	.036	3	1
UCEC	JNK2 →	+0.212	+2.700	.018	.006	3	1
UCEC	MEK1 →	+0.394	+3.321	.016	.010	3	1
UCEC	MSH2 →	-0.287	-2.000	.005	.032	3	1
UCEC	p62 Lck ligand →	+0.330	+3.009	.024	.019	3	1
UCEC	Rab25 →	-0.429	-2.000	.004	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK_pT183_Y185 by RANBP3L expression — SKCM

Explore this box plot interactively →