RANBP3

Across TCGA pan-cancer cohorts, RANBP3 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RANBP3’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where RANBP3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RANBP3 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

PDAC, HNSC, and LSCC are the cancer types where RANBP3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RANBP3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.299	<.001	9	view →
HNSC	Male	All	+0.149	<.001	6	view →
LSCC	Male	All	+0.104	<.001	4	view →
CCRCC	Male	All	+0.092	<.001	4	view →
LUAD	Male	All	+0.080	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RANBP3–PDAC

Open the PDAC breakdown →