RANBP3

Across TCGA patient cohorts, RANBP3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANBP3-associated genes across cancer lineages are ERK2, ATM, and Beclin. Each is linked with RANBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RANBP3-to-partner and partner-to-RANBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RANBP3-low versus RANBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP3→partner) and Y-score (partner→RANBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.205	+3.459	.004	.005	3	2
UCEC	ATM →	-0.568	-2.169	<.001	.003	3	2
UCEC	Beclin →	-0.096	-3.459	.006	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.571	+1.894	.010	.030	3	2
UCEC	eIF4E →	+0.166	+1.750	.036	.049	3	1
UCEC	FoxM1 →	+0.233	+1.765	.016	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by RANBP3 expression — UCEC

Explore this box plot interactively →