RANBP2

Across TCGA pan-cancer cohorts, RANBP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RANBP2 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RANBP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RANBP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where RANBP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.854	0.371	<.001	37	view →
CCRCC	OS	Median	All	0.891	1.000	.004	33	view →
HNSC	DFS	Tertile	III,IV	0.670	0.906	.005	30	view →
LUAD	DFS	Quartile	All	0.957	0.796	.007	27	view →
COAD	DFS	Median	All	1.000	0.889	.024	24	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RANBP2–LSCC (DFS)

Open the LSCC breakdown →