RANBP2

Across TCGA patient cohorts, RANBP2 mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANBP2-associated genes across cancer lineages are Caspase-7-cleavedD198, PREX1, and FOXO3a_pS318_S321. Each is linked with RANBP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both RANBP2-to-partner and partner-to-RANBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RANBP2-low versus RANBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP2→partner) and Y-score (partner→RANBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.433	+1.452	.003	.002	3	5
SKCM	PREX1 →	-0.328	-2.906	.004	.001	3	4
STAD	FOXO3a_pS318_S321 →	-0.287	-3.000	<.001	.033	3	4
STAD	TFRC →	+0.762	+2.321	.006	.034	3	4
STAD	CDK1 →	+0.426	+3.169	.006	.018	3	4
UCEC	Cyclin-B1 →	+0.624	+2.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Caspase-7-cleavedD198 by RANBP2 expression — UCEC

Explore this box plot interactively →