RAN

Across TCGA patient cohorts, RAN RNA expression is significantly associated with the protein abundance of many other proteins, with 20,064 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RAN-associated proteins across cancer lineages are MCM5, CDK1, and DDX21_S89. Each is linked with RAN in more than 8 cancer types. Because this analysis shows association rather than direction, both RAN-to-partner and partner-to-RAN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAN versus MCM5 in LSCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RAN→partner) and Y-score (partner→RAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM5 →	+0.738	+0.579	<.001	<.001	3	9
LSCC	CDK1 →	+0.699	+0.490	<.001	<.001	3	8
BRCA	DDX21_S89 →	+1.124	+0.537	<.001	<.001	3	8
LSCC	XPO5 →	+0.764	+0.644	<.001	<.001	3	8
LSCC	SMC2 →	+0.677	+0.587	<.001	<.001	3	8
GBM	RRM1 →	+0.609	+0.415	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,064 associations by consensus.

RAN vs MCM5 — LSCC

Explore this scatter interactively →