RAN

Across TCGA patient cohorts, RAN mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAN-associated genes across cancer lineages are MIR6846, LINC02348, and RNA5SP414. Each is linked with RAN in more than 1 cancer types. Because this analysis shows association rather than direction, both RAN-to-partner and partner-to-RAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6846 grouped by RAN-low versus RAN-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAN→partner) and Y-score (partner→RAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6846 →	+0.572	+8.055	<.001	.007	3	1
UCEC	LINC02348 →	+0.393	+2.678	.002	.004	3	1
UCEC	RNA5SP414 →	+0.984	+2.992	<.001	.001	3	1
UCEC	RNA5SP411 →	+1.485	+2.656	<.001	.003	3	1
UCEC	RPS29P32 →	+0.401	+2.792	.004	.006	3	1
SKCM	RNU6-92P →	+0.332	+4.979	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

MIR6846 by RAN expression — BRCA

Explore this box plot interactively →