RAN

Across TCGA patient cohorts, RAN mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAN-associated genes across cancer lineages are EGFR_pY1068, Myosin-IIa_pS1943, and STAT3_pY705. Each is linked with RAN in more than 1 cancer types. Because this analysis shows association rather than direction, both RAN-to-partner and partner-to-RAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RAN-low versus RAN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAN→partner) and Y-score (partner→RAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.380	-3.000	.008	.037	3	1
UCEC	Myosin-IIa_pS1943 →	+0.288	+3.013	.015	.019	3	1
UCEC	STAT3_pY705 →	-0.455	-3.000	.002	.037	3	1
UCEC	MEK1 →	+0.585	+3.000	.005	.036	2	1
UCEC	MSH2 →	-0.344	-3.000	.009	.037	2	1
UCEC	Shc_pY317 →	-0.239	-3.000	.006	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

EGFR_pY1068 by RAN expression — UCEC

Explore this box plot interactively →