RAN

Across TCGA cell cohorts, RAN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,226 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RAN-associated GO terms across cancer lineages are DNA replication, rRNA processing, and Double-strand break repair via break-induced replication. Each is linked with RAN in more than 16 cancer types. Because this analysis shows association rather than direction, both RAN-to-partner and partner-to-RAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by RAN-low versus RAN-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAN→partner) and Y-score (partner→RAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA replication →	+0.106	+0.711	.003	.002	3	17
BONE	rRNA processing →	+0.102	+0.621	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via break-induced replication →	+0.265	+1.157	<.001	<.001	3	17
BONE	Maturation of SSU-rRNA →	+0.133	+0.871	<.001	.004	3	16
BONE	Maturation of 5.8S rRNA →	+0.169	+0.971	<.001	<.001	3	16
LIVER	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.153	+0.892	.009	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,226 associations by consensus.

DNA replication by RAN expression — OESOPHAGUS

Explore this box plot interactively →