RAMP3

Across TCGA pan-cancer cohorts, RAMP3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RAMP3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RAMP3 RNA is repressed in tumor relative to normal tissue. In most cancer types RAMP3 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and KICH are the cancer types where RAMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−3.623	<.001	11	view →
KIRP	Male	All	−2.999	<.001	11	view →
KICH	Male	II,III,IV	−2.808	<.001	11	view →
LUSC	Male	III,IV	−3.900	<.001	9	view →
BLCA	All	All	−1.128	<.001	6	view →
BRCA	All	II,III,IV	−0.884	<.001	6	view →
THCA	All	IV	−1.272	.006	4	view →
LIHC	Male	All	−0.726	.004	4	view →
KIRC	All	All	+0.483	.002	3	view →
ESCA	Male	All	+1.367	.009	2	view →
UCEC	All	All	−1.249	.016	2	view →
READ	Female	All	−0.561	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RAMP3–LUAD

Open the LUAD breakdown →