RAMP2

Across TCGA patient cohorts, RAMP2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAMP2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and A-Raf_pS299. Each is linked with RAMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAMP2-to-partner and partner-to-RAMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RAMP2-low versus RAMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAMP2→partner) and Y-score (partner→RAMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-1.986	.039	.032	3	1
UCEC	EGFR_pY1068 →	-0.255	-3.169	.024	.019	3	1
UCEC	A-Raf_pS299 →	-0.180	-3.169	<.001	.019	3	1
UCEC	G6PD →	-0.300	-2.000	.040	.032	3	1
UCEC	HER3_pY1289 →	+0.076	+2.189	.049	.034	3	1
UCEC	JNK2 →	+0.236	+3.331	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by RAMP2 expression — UCEC

Explore this box plot interactively →