RAMAC

Across TCGA pan-cancer cohorts, RAMAC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAMAC data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RAMAC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAMAC expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where RAMAC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	1.000	0.889	.002	17	view →
CCRCC	OS	Tertile	All	0.746	0.962	.013	5	view →
PDAC	DFS	Quartile	All	0.903	0.342	.006	3	view →
LUAD	DFS	Tertile	All	1.000	0.353	.044	2	view →
LSCC	DFS	Median	II,III,IV	0.598	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAMAC–HNSC (DFS)

Open the HNSC breakdown →