Across TCGA patient cohorts, RALYL mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALYL-associated genes across cancer lineages are ERK2, c-Kit, and SF2. Each is linked with RALYL in more than 1 cancer types. Because this analysis shows association rather than direction, both RALYL-to-partner and partner-to-RALYL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALYL→partner) and Y-score (partner→RALYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ERK2 →	+0.200	+2.195	.028	.034	3	2
UCEC	c-Kit →	-0.166	-2.308	.037	.033	3	2
LUSC	SF2 →	+0.103	+3.000	.044	.033	3	1
LUSC	Cyclin-E2 →	+0.125	+2.825	.024	.033	3	1
COAD	NF2 →	+0.259	+2.178	.004	.035	3	1
SKCM	PREX1 →	-0.335	-2.321	.040	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

RALYL survival (RNA) · tumor vs normal (RNA) · all RALYL data types