RALY

Across TCGA pan-cancer cohorts, RALY RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RALY’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RALY RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RALY is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where RALY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RALY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.151	<.001	12	view →
KIRC	Female	All	+0.602	<.001	12	view →
COAD	Female	All	+0.565	<.001	10	view →
LIHC	Female	II,III,IV	+1.777	<.001	9	view →
KIRP	All	II,III,IV	+0.875	<.001	9	view →
STAD	Male	II,III,IV	+1.092	<.001	8	view →
BLCA	All	All	+0.616	<.001	8	view →
BRCA	All	III,IV	+0.718	<.001	6	view →
LUSC	All	II,III,IV	+0.482	<.001	6	view →
LUAD	All	All	+0.206	.001	6	view →
CHOL	Male	All	+2.345	<.001	5	view →
UCEC	All	All	+0.369	.013	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RALY–HNSC

Open the HNSC breakdown →