RALGPS2

Across TCGA patient cohorts, RALGPS2 mutation is significantly associated with the RNA expression of many other genes, with 1,389 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGPS2-associated genes across cancer lineages are KRTAP4-3, EIF4E2P2, and IDI1P2. Each is linked with RALGPS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RALGPS2-to-partner and partner-to-RALGPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-3 grouped by RALGPS2-low versus RALGPS2-high in GBM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS2→partner) and Y-score (partner→RALGPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KRTAP4-3 →	+0.123	+5.584	<.001	.003	3	3
COAD	EIF4E2P2 →	+0.550	+3.567	<.001	.009	3	3
GBM	IDI1P2 →	+0.101	+4.969	<.001	.009	3	2
SKCM	NF1P5 →	+0.060	+2.770	<.001	.006	3	2
SKCM	RNU6-171P →	+0.147	+4.049	<.001	.007	3	2
SKCM	SNORD90 →	+0.167	+3.021	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,389 associations by consensus.

KRTAP4-3 by RALGPS2 expression — GBM

Explore this box plot interactively →