RALGPS2

Across TCGA patient cohorts, RALGPS2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGPS2-associated genes across cancer lineages are eEF2, GAPDH, and Shc_pY317. Each is linked with RALGPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RALGPS2-to-partner and partner-to-RALGPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RALGPS2-low versus RALGPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS2→partner) and Y-score (partner→RALGPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+2.459	.013	.019	3	2
UCEC	GAPDH →	+0.460	+2.000	.029	.010	3	2
UCEC	Shc_pY317 →	-0.127	-1.584	.033	.036	3	2
UCEC	TFRC →	+0.527	+1.584	.011	.036	3	2
UCEC	ATM →	-0.624	-3.687	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.642	+3.169	.003	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eEF2 by RALGPS2 expression — UCEC

Explore this box plot interactively →