RALGPS2

Across TCGA cell cohorts, RALGPS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,354 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RALGPS2-associated GO terms across cancer lineages are Regulation of GTPase activity, Rho protein signal transduction, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with RALGPS2 in more than 10 cancer types. Because this analysis shows association rather than direction, both RALGPS2-to-partner and partner-to-RALGPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of GTPase activity grouped by RALGPS2-low versus RALGPS2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS2→partner) and Y-score (partner→RALGPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of GTPase activity →	+0.044	+0.765	.001	<.001	3	11
OESOPHAGUS	Rho protein signal transduction →	+0.152	+1.562	.007	.004	3	10
SOFT_TISSUE	Regulation of alternative mRNA splicing, via spliceosome →	+0.098	+1.894	<.001	<.001	3	9
STOMACH	Golgi vesicle transport →	+0.077	+1.482	<.001	<.001	3	9
OESOPHAGUS	Small GTPase-mediated signal transduction →	+0.062	+1.505	.001	<.001	3	9
LUNG_NSCLC_LUAD	Ketone metabolic process →	-0.090	-0.738	<.001	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,354 associations by consensus.

Regulation of GTPase activity by RALGPS2 expression — LARGE_INTESTINE

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