RALGPS2

Across TCGA cell cohorts, RALGPS2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RALGPS2-associated genes across cancer lineages are SH3GL2, NUDT10, and ZNF831. Each is linked with RALGPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RALGPS2-to-partner and partner-to-RALGPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by RALGPS2-low versus RALGPS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS2→partner) and Y-score (partner→RALGPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.234	+3.252	.002	.009	3	1
LARGE_INTESTINE	NUDT10 →	+0.386	+3.555	<.001	.003	3	1
LARGE_INTESTINE	ZNF831 →	+0.012	+2.688	<.001	.008	3	1
LARGE_INTESTINE	DACH2 →	+0.333	+2.817	<.001	.007	3	1
LARGE_INTESTINE	FUT5 →	+0.021	+2.657	<.001	.007	3	1
LARGE_INTESTINE	C1orf189 →	+0.126	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SH3GL2 by RALGPS2 expression — LARGE_INTESTINE

Explore this box plot interactively →