RALGPS1

Across TCGA patient cohorts, RALGPS1 mutation is significantly associated with the RNA expression of many other genes, with 2,786 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGPS1-associated genes across cancer lineages are SNORD115-20, NANS, and NOL12. Each is linked with RALGPS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RALGPS1-to-partner and partner-to-RALGPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD115-20 grouped by RALGPS1-low versus RALGPS1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS1→partner) and Y-score (partner→RALGPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SNORD115-20 →	+0.398	+7.954	<.001	.008	3	3
UCEC	NANS →	+0.451	+2.850	<.001	.001	3	3
UCEC	NOL12 →	+0.282	+1.732	.001	.001	3	2
UCEC	PANO1 →	+0.359	+2.565	<.001	<.001	3	2
SKCM	GTF2H5 →	+0.433	+3.220	.004	.009	3	2
CESC	RNU6-821P →	+0.350	+5.144	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,786 associations by consensus.

SNORD115-20 by RALGPS1 expression — HNSC

Explore this box plot interactively →