RALGPS1

Across TCGA patient cohorts, RALGPS1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGPS1-associated genes across cancer lineages are PCNA, PDCD4, and Annexin-1. Each is linked with RALGPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RALGPS1-to-partner and partner-to-RALGPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RALGPS1-low versus RALGPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS1→partner) and Y-score (partner→RALGPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.212	+1.584	.003	.009	3	2
UCEC	PDCD4 →	-0.340	-1.321	.031	.029	3	2
UCEC	Annexin-1 →	+0.565	+2.434	.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.798	+2.019	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.569	+2.321	.002	.005	3	2
UCEC	14-3-3_beta →	-0.094	-1.571	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PCNA by RALGPS1 expression — UCEC

Explore this box plot interactively →