RALGPS1

Across TCGA cell cohorts, RALGPS1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RALGPS1-associated genes across cancer lineages are SLC10A2, GPR149, and PRAMEF26. Each is linked with RALGPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RALGPS1-to-partner and partner-to-RALGPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC10A2 grouped by RALGPS1-low versus RALGPS1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGPS1→partner) and Y-score (partner→RALGPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
CNS	GPR149 →	+0.022	+5.321	<.001	.005	3	1
CNS	PRAMEF26 →	+0.270	+5.754	.005	.002	3	1
CNS	KCNK16 →	+0.151	+4.981	<.001	.008	3	1
LARGE_INTESTINE	PWWP3A →	+0.738	+3.064	.003	.009	3	1
LARGE_INTESTINE	MROH2A →	+0.332	+3.302	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SLC10A2 by RALGPS1 expression — SKIN

Explore this box plot interactively →