RALGAPA1

Across TCGA patient cohorts, RALGAPA1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGAPA1-associated genes across cancer lineages are p62 Lck ligand, ATM, and beta-Catenin. Each is linked with RALGAPA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RALGAPA1-to-partner and partner-to-RALGAPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RALGAPA1-low versus RALGAPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGAPA1→partner) and Y-score (partner→RALGAPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.461	+2.099	<.001	<.001	3	4
COAD	ATM →	-0.650	-3.161	<.001	.019	3	3
COAD	beta-Catenin →	-0.715	-3.161	.027	.019	3	3
SKCM	PKC-b-II_pS660 →	-0.262	-3.321	.040	.009	3	3
UCEC	eIF4E →	+0.197	+1.857	.001	<.001	3	3
UCEC	PDCD4 →	-0.534	-2.169	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

p62 Lck ligand by RALGAPA1 expression — UCEC

Explore this box plot interactively →