RALGAPA1

Across TCGA cell cohorts, RALGAPA1 mutation is significantly associated with the RNA expression of many other genes, with 341 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RALGAPA1-associated genes across cancer lineages are SPINK9, ANKRD66, and DGKK. Each is linked with RALGAPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RALGAPA1-to-partner and partner-to-RALGAPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by RALGAPA1-low versus RALGAPA1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGAPA1→partner) and Y-score (partner→RALGAPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	2
BREAST	ANKRD66 →	+0.015	+3.781	<.001	.009	3	2
SOFT_TISSUE	DGKK →	+0.258	+3.865	.004	.006	3	1
STOMACH	CYLC1 →	+0.163	+3.662	<.001	.001	3	1
LUNG_NSCLC_LUAD	GNAT1 →	+0.173	+3.707	.001	.009	3	1
LUNG_NSCLC_LUAD	CELA3A →	+0.049	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 341 associations by consensus.

SPINK9 by RALGAPA1 expression — SKIN

Explore this box plot interactively →