RALGAPA1

Across TCGA cell cohorts, RALGAPA1 mutation is significantly associated with the mutation status of many other genes, with 3,267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RALGAPA1-associated genes across cancer lineages are SOBP, UBR2, and CRYBG3. Each is linked with RALGAPA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RALGAPA1-to-partner and partner-to-RALGAPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOBP grouped by RALGAPA1-low versus RALGAPA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGAPA1→partner) and Y-score (partner→RALGAPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOBP →	+2.493	+2.758	.007	.007	1	5
BLOOD_Lymphoma	UBR2 →	+5.108	+3.847	.001	.001	1	5
BLOOD_Leukemia	CRYBG3 →	+3.247	+3.050	.008	.008	1	5
SKIN	ARHGEF12 →	+4.638	+4.638	<.001	<.001	1	5
SKIN	SCN7A →	+2.352	+4.062	.004	.004	1	5
BLOOD_Lymphoma	INO80D →	+3.523	+3.232	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,267 associations by consensus.

SOBP by RALGAPA1 expression — BLOOD_Leukemia

Explore this box plot interactively →