RALA

Across TCGA pan-cancer cohorts, RALA mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RALA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RALA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RALA is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, COAD, and LSCC are the cancer types where RALA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RALA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.758	<.001	9	view →
COAD	Male	II,III,IV	+0.286	<.001	9	view →
LSCC	Female	All	−0.683	<.001	8	view →
HNSC	All	All	−0.217	<.001	8	view →
PDAC	All	II,III,IV	+0.242	.005	5	view →
OV	All	All	+0.746	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RALA–LUAD

Open the LUAD breakdown →