RAI2

Across TCGA cell cohorts, RAI2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAI2-associated genes across cancer lineages are TFAP2D, GJE1, and CLRN2. Each is linked with RAI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAI2-to-partner and partner-to-RAI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFAP2D grouped by RAI2-low versus RAI2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAI2→partner) and Y-score (partner→RAI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TFAP2D →	+0.186	+5.781	<.001	.001	3	1
BLOOD_Leukemia	GJE1 →	+0.017	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CLRN2 →	+0.043	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.047	+2.994	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3E →	+0.285	+3.592	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TFAP2D by RAI2 expression — BREAST

Explore this box plot interactively →