RAI1

Across TCGA pan-cancer cohorts, RAI1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAI1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RAI1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RAI1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where RAI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.945	0.712	.007	21	view →
PDAC	OS	Tertile	All	0.435	0.632	.005	18	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
HNSC	DFS	Quartile	III,IV	0.706	0.908	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAI1–LSCC (OS)

Open the LSCC breakdown →