RAI1

Across TCGA patient cohorts, RAI1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAI1-associated genes across cancer lineages are FASN, Caspase-7-cleavedD198, and ERK2. Each is linked with RAI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAI1-to-partner and partner-to-RAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RAI1-low versus RAI1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAI1→partner) and Y-score (partner→RAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.469	+2.823	.022	.034	2	4
STAD	Caspase-7-cleavedD198 →	+1.293	+3.000	<.001	.034	2	4
UCEC	ERK2 →	+0.143	+2.000	.003	.002	3	3
UCEC	MEK1 →	+0.370	+2.459	<.001	<.001	3	3
UCEC	Rad50 →	-0.148	-0.830	.017	.049	3	3
UCEC	4E-BP1 →	+0.307	+1.509	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

FASN by RAI1 expression — STAD

Explore this box plot interactively →