RAI1-AS1

Across TCGA pan-cancer cohorts, RAI1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RAI1-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RAI1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RAI1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, BLCA, and UVM are the cancer types where RAI1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	III,IV	0.680	0.393	<.001	53	view →
BLCA	OS	Quartile	III,IV	0.609	0.359	.010	31	view →
UVM	OS	Tertile	All	0.627	0.948	.002	27	view →
GBM	DFS	Tertile	All	0.179	0.298	.003	27	view →
ESCA	OS	Tertile	III,IV	0.639	0.314	.010	26	view →
OV	DFS	Quartile	IV	0.254	0.486	.021	20	view →
READ	OS	Tertile	IV	0.077	1.000	.014	19	view →
KIRC	DFS	Median	III,IV	0.530	0.723	.007	12	view →
THCA	OS	Quartile	All	0.941	0.990	.010	12	view →
PCPG	DFS	Median	All	0.953	0.713	.014	12	view →
STAD	OS	Tertile	III,IV	0.446	0.208	.018	11	view →
COAD	OS	Quartile	All	0.929	0.773	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RAI1-AS1–SKCM (DFS)

Open the SKCM breakdown →