RAG2

Across TCGA cell cohorts, RAG2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAG2-associated genes across cancer lineages are CCL18, GSG1L2, and KRT85. Each is linked with RAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAG2-to-partner and partner-to-RAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL18 grouped by RAG2-low versus RAG2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAG2→partner) and Y-score (partner→RAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCL18 →	+0.025	+2.949	<.001	.001	3	2
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRT85 →	+0.037	+2.860	<.001	.006	3	1
LUNG_NSCLC_LUAD	CLVS2 →	+0.180	+3.339	<.001	.001	3	1
LUNG_NSCLC_LUAD	KRT82 →	+0.026	+3.215	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C1orf232 →	+0.021	+2.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CCL18 by RAG2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →