RAG1

Across TCGA patient cohorts, RAG1 mutation is significantly associated with the RNA expression of many other genes, with 6,056 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAG1-associated genes across cancer lineages are RER1, RAD51, and FMO4. Each is linked with RAG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAG1-to-partner and partner-to-RAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RER1 grouped by RAG1-low versus RAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAG1→partner) and Y-score (partner→RAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RER1 →	+0.204	+2.294	.001	<.001	3	4
UCEC	RAD51 →	+0.823	+2.180	<.001	<.001	3	4
COAD	FMO4 →	-0.548	-3.969	<.001	<.001	3	4
UCEC	UBE2T →	+0.507	+1.593	<.001	<.001	3	4
LUSC	FCER1A →	-0.988	-3.459	.002	.005	3	4
SKCM	ZNF662 →	-0.517	-1.929	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,056 associations by consensus.

RER1 by RAG1 expression — UCEC

Explore this box plot interactively →