RAG1

Across TCGA cell cohorts, RAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,504 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAG1-associated GO terms across cancer lineages are Pre-B cell allelic exclusion, Regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with RAG1 in more than 12 cancer types. Because this analysis shows association rather than direction, both RAG1-to-partner and partner-to-RAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pre-B cell allelic exclusion grouped by RAG1-low versus RAG1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAG1→partner) and Y-score (partner→RAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Pre-B cell allelic exclusion →	-0.438	-0.330	<.001	<.001	3	13
OVARY	Regulation of syncytium formation by plasma membrane fusion →	+0.091	+0.406	.003	.004	3	11
OVARY	Regulation of myoblast fusion →	+0.079	+0.375	.002	.002	3	10
SOFT_TISSUE	Negative regulation of myoblast fusion →	+0.090	+0.448	<.001	.001	3	10
SOFT_TISSUE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.090	+0.441	<.001	.001	3	9
OVARY	Cytoplasmic translation →	+0.062	+0.335	.004	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,504 associations by consensus.

Pre-B cell allelic exclusion by RAG1 expression — OVARY

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