RAG1

Across TCGA cell cohorts, RAG1 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAG1-associated genes across cancer lineages are TLE6, USP18, and PAX9. Each is linked with RAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAG1-to-partner and partner-to-RAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE6 grouped by RAG1-low versus RAG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAG1→partner) and Y-score (partner→RAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TLE6 →	+0.934	+3.125	<.001	.008	3	2
BLOOD_Leukemia	USP18 →	+1.212	+3.489	.004	.001	3	2
LARGE_INTESTINE	PAX9 →	+0.594	+2.628	.008	.002	3	2
LARGE_INTESTINE	RPL17 →	+0.791	+2.628	<.001	.002	3	2
STOMACH	C1orf146 →	+0.036	+4.432	<.001	.003	3	2
BLOOD_Lymphoma	OR11G2 →	+0.012	+4.867	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

TLE6 by RAG1 expression — LARGE_INTESTINE

Explore this box plot interactively →